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Clin Infect Dis ; 72(7): 1256-1258, 2021 04 08.
Article in English | MEDLINE | ID: covidwho-1174888

ABSTRACT

We report a case of a man with COVID-19 who developed acute hepatotoxicity related to remdesivir with probable interaction of P-glycoprotein (P-gp) inhibitors. Until further details on this interaction become available, we recommend physicians to be cautious with the prescription of P-gp inhibitors in patients receiving remdesivir therapy.


Subject(s)
COVID-19 Drug Treatment , Chemical and Drug Induced Liver Injury , ATP Binding Cassette Transporter, Subfamily B , Adenosine Monophosphate/analogs & derivatives , Alanine/analogs & derivatives , Antiviral Agents/adverse effects , Chemical and Drug Induced Liver Injury/etiology , Humans , Male , SARS-CoV-2
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